 sr java.util.Hashtable%!J F 
loadFactorI 	thresholdxp?@    w    t 'experiments1.locations12.Coordinates[1]t 19.0t !experiments1.locations18.SPI_Unitt tt &experiments3.contrast.stimulusModalityt falset #experiments3.locations0.Location_IDt 0t experiments0.locations4.Extendt  t experiments6.imagingModalityt fMRIt experiments4.conditions.lengtht 2t experiments5.Sessions.lengtht 2t experiments3.locations1.Extendq ~ t &experiments4.locations3.Coordinates[0]t 51.0t !experiments0.locations19.SPI_Unitt tt 'experiments0.locations18.Coordinates[2]t -6.0t experiments3.activationst truet tasks0.stimuly0.Stimulus_typet Letterst &experiments2.locations1.Coordinates[1]t 10.0t experiments1.lowLevelControlq ~ t &experiments3.locations4.Coordinates[2]t -11.0t ,experiments5.functional_modalities0.Commentst  t 'experiments1.locations12.Coordinates[0]t 36.0t &experiments5.Behavioral_domain0.effectt Cognition.Memory.Workingt tasks4.stimuly0.stimulusContentt  t !experiments0.contrast.descriptiont  t Other_countryt nullt !tasks0.stimuly0.Stimulus_modalityt Visualt experiments4.contrast.groupq ~ t #experiments3.locations1.Location_IDt 1t %experiments0.locations17.Publ_SPI_Valt 4.50t population1.IDCq ~ -t /experiments1.contrast.experienceDependentChangeq ~ t  experiments2.locations2.SPI_Unitt tt 'experiments0.locations18.Coordinates[1]t 21.0t 'experiments1.locations20.Coordinates[2]t 1.0t experiments2.lowLevelControlq ~ t &experiments2.locations1.Coordinates[0]t 22.0t &experiments3.locations4.Coordinates[1]t 15.0t experiments1.locations6.Extendq ~ t experiments4.activationsq ~ t experiments4.contrast.sessionq ~ t population0handednessRatioq ~ -t experiments0.Namet 2-Back vs. Fixation, Normalst va.mriSmoothingKernalt  t authors.lengtht 15t &experiments1.locations2.Coordinates[2]t -6.0t !experiments0.locations13.SPI_Unitt tt #experiments3.locations2.Location_IDt 2t 'experiments1.locations16.Coordinates[2]t 5.0t tasks1.stimuly0.stimulusContentq ~ )t  tasks0.External_variables.lengtht 2t 'experiments0.locations18.Coordinates[0]t -26.0t 'experiments1.locations20.Coordinates[1]t 16.0t )population0externalAssessmentsDescriptionq ~ -t !experiments2.contrast.instructionq ~ t &experiments3.locations4.Coordinates[0]t 36.0t tasks4.response0.descriptiont  t experiments2.contrast.groupq ~ t tasks2.task_namet 2-Backt %experiments1.locations11.Publ_SPI_Valt 7.23t  experiments1.locations7.SPI_Unitt tt )experiments0.functional_modalities.lengtht 1t experiments5.activationsq ~ t "experiments3.contrast.stimulusRateq ~ t %experiments1.locations12.Publ_SPI_Valt 7.08t &experiments1.locations2.Coordinates[1]t 25.0t &experiments2.locations5.Coordinates[2]t 31.0t 'experiments1.locations16.Coordinates[1]t 16.0t experiments2.conditions.lengtht 2t $experiments0.locations5.Publ_SPI_Valt 8.15t $experiments1.locations7.Publ_SPI_Valt 9.16t  tasks1.instractions0.Instructiont Discriminatet $experiments5.locations0.Publ_SPI_Valt 4.48t #experiments3.locations3.Location_IDt 3t experiments1.locations1.Extendq ~ t 'experiments1.locations20.Coordinates[0]t 53.0t experiments1.locations22.Extendq ~ t  experiments4.locations3.SPI_Unitt tt $experiments1.experiment_class.lengtht 1t &experiments1.locations0.Coordinates[2]t 49.0t experiments6.Contexts.lengtht 2t &experiments1.locations2.Coordinates[0]t -30.0t &experiments2.locations5.Coordinates[1]t 15.0t experiments6.activationsq ~ t &experiments2.contrast.responseModalityq ~ t 'experiments1.locations16.Coordinates[0]t -42.0t "experiments1.contrast.responseRateq ~ t ,experiments2.functional_modalities0.Modalityt fMRIt experiments6.Sessions1t After Quetiapinet experiments6.Sessions0t Before Quetiapinet  experiments1.locations1.SPI_Unitt tt #experiments3.locations4.Location_IDt 4t %experiments6.Behavioral_domain.lengtht 2t experiments1.locations18.Extendq ~ t tasks3.instractions.lengtht 1t experiments6.singleSubjectq ~ t experiments2.commentst  t &experiments1.locations0.Coordinates[1]t -52.0t &experiments2.locations3.Coordinates[2]t -8.0t "experiments6.contrast.responseRateq ~ t &experiments2.locations5.Coordinates[0]t 46.0t experiments2.locations3.Extendq ~ t !experiments5.contrast.descriptiont  t tasks1.stimuly0.Stimulus_descrt .subjects viewed letters on a blurry backgroundt 
Other_cityq ~ -t experiments2.contrast.sessionq ~ t #experiments3.locations5.Location_IDt 5t tasks0.response0.Responce_typet Button Presst &experiments1.locations0.Coordinates[0]t -34.0t  experiments0.locations6.SPI_Unitt tt &experiments2.locations3.Coordinates[1]t 25.0t %experiments3.Behavioral_domain.lengtht 1t "experiments1.contrast.stimulusTypeq ~ t experiments3.singleSubjectq ~ t experiments6.Contexts1t Drug Effectst experiments6.Contexts0t Disease Effectst experiments6.contrast.groupq ~ t &experiments0.locations1.Coordinates[2]t 38.0t population0.concurrentq ~ -t experiments0.locations13.Extendq ~ t experiments1.locations13.Extendq ~ t experiments2.Sessions0q ~ t &experiments1.contrast.stimulusModalityq ~ t  experiments3.locations2.SPI_Unitt tt ,experiments5.functional_modalities0.Modalityq ~ t experiments0.locations8.Extendq ~ t "experiments6.contrast.stimulusTypeq ~ t 'experiments1.locations22.Coordinates[2]t 39.0t *experiments6.population_groups_used.lengtht 1t &experiments6.contrast.externalVariableq ~ t &experiments2.locations3.Coordinates[0]t -30.0t $experiments1.locations0.Publ_SPI_Valt 14.49t $experiments2.locations2.Publ_SPI_Valt 5.97t $experiments3.locations4.Publ_SPI_Valt 3.98t tasks0.stimuly.lengtht 1t va.vbmDescriptiont SPM99, but used the Brett transform to convert to Tal space (author communication).

This paper was edited by the BatchEdit program on Tue Jan 27 15:23:01 CST 2015. The old value was as follows:
     Brain Template: Brett Transform - SPM99t $experiments3.locations5.Publ_SPI_Valt 3.77t &experiments0.locations1.Coordinates[1]t -42.0t experiments5.experiment_class0t n-backt &experiments1.locations4.Coordinates[2]t 43.0t %experiments0.Behavioral_domain.lengtht 1t &experiments3.Behavioral_domain0.effectt Cognition.Memory.Workingt experiments0.singleSubjectq ~ t 'experiments1.locations18.Coordinates[2]t 49.0t  experiments0.locations0.SPI_Unitt tt tasks2.Descriptiont  t $experiments4.experiment_class.lengtht 1t 'experiments1.locations22.Coordinates[1]t 23.0t &experiments6.locations0.Coordinates[2]t 3.0t !tasks1.stimuly0.Stimulus_modalityq ~ /t  experiments2.locations7.SPI_Unitt tt "experiments4.contrast.responseTypeq ~ t tasks1.External_descriptiont  t !experiments1.locations17.SPI_Unitt tt &experiments0.locations1.Coordinates[0]t -46.0t experiments6.Sessions.lengtht 2t &experiments1.locations4.Coordinates[1]t 16.0t &experiments2.locations7.Coordinates[2]t -4.0t experiments0.locations3.Extendq ~ t %experiments0.locations18.Publ_SPI_Valt 14.19t 'experiments1.locations18.Coordinates[1]t 14.0t population.lengtht 2t !experiments0.locations18.SPI_Unitt tt !experiments1.locations12.SPI_Unitt tt tasks3.Descriptiont  t 'experiments1.locations22.Coordinates[0]t -4.0t &experiments6.locations0.Coordinates[1]t -56.0t population0ageMatchedControlsq ~ -t experiments0.contrast.sessionq ~ t experiments4.locations3.Extendq ~ t &experiments1.locations4.Coordinates[0]t -28.0t tasks4.stimuly0.Stimulus_descrt crosst &experiments2.locations7.Coordinates[1]t 13.0t &experiments6.Behavioral_domain1.effectt 3Pharmacology.Psychiatric Medications.Antipsychoticst 'experiments1.locations18.Coordinates[0]t -4.0t #experiments0.locations1.Location_IDt 1t submiter.Coder_Addresst The University of Texas Health Science Center San Antonio
Research Imaging Center, M/C 6240
7703 Floyd Curl Drive
San Antonio TX, 78229-3900

t experiments3.lowLevelControlq ~ t &experiments0.locations5.Coordinates[2]t 10.0t tasks3.response0.Responce_typet Button Presst $experiments0.population_groups_used0t Normals t  experiments2.locations1.SPI_Unitt tt &experiments6.locations0.Coordinates[0]t -12.0t tasks4.instractions.lengtht 1t tasks4.Descriptiont  t $experiments1.locations15.Location_IDt 15t /experiments6.contrast.experienceDependentChangeq ~ t #experiments5.locations0.Location_IDt 0t !population0.icdGeneralCode.lengtht 0t experiments1.locations5.Extendq ~ t experiments.lengtht 7t &experiments2.locations7.Coordinates[0]t -26.0t %experiments1.locations13.Publ_SPI_Valt 6.61t experiments3.experiment_class0q ~ t &experiments6.contrast.stimulusModalityq ~ t tasks4.stimuly.lengtht 1t tasks1.response0.descriptiont  t #experiments0.locations8.Location_IDt 8t experiments4.lowLevelControlq ~ t $experiments0.locations6.Publ_SPI_Valt 7.52t $experiments1.locations8.Publ_SPI_Valt 5.49t &experiments0.locations5.Coordinates[1]t -11.0t #experiments0.locations2.Location_IDt 2t "experiments0.contrast.stimulusRateq ~ t &experiments0.contrast.responseModalityq ~ t &experiments1.locations8.Coordinates[2]t 39.0t $experiments1.locations9.Publ_SPI_Valt 7.69t tasks2.stimuly0.Stimulus_typeq ~ t  experiments1.locations6.SPI_Unitt tt population1Mean_Aget 34t &tasks1.instractions0.Instruction_descrt 9subjects responded with a button press for the letter "X"t $experiments1.locations16.Location_IDt 16t tasks3.response0.effectt Handt !experiments1.contrast.instructionq ~ t submiter.isAuthorq ~ t $experiments1.locations10.Location_IDt 10t "experiments5.contrast.stimulusRateq ~ t &experiments0.locations3.Coordinates[2]t 23.0t &experiments0.locations5.Coordinates[0]t -12.0t population1Gendert Mixedt #experiments0.locations9.Location_IDt 9t &experiments1.locations8.Coordinates[1]t -52.0t experiments0.locations18.Extendq ~ t #experiments0.locations3.Location_IDt 3t experiments1.locations0.Extendt  t %experiments0.locations10.Publ_SPI_Valt 7.00t experiments1.locations21.Extendq ~ t tasks2.stimuly.lengtht 1t $experiments1.locations17.Location_IDt 17t population1Total_Subjectst 12t tasks0.Descriptiont  t tasks3.task_namet 2-Back Degradedt $experiments1.locations11.Location_IDt 11t &experiments0.locations3.Coordinates[1]t 11.0t Lab0t University of Municht &experiments1.locations6.Coordinates[2]t 21.0t experiments1.conditions1q ~t &experiments1.locations8.Coordinates[0]t 38.0t experiments1.conditions0t Fixationt /experiments2.contrast.experienceDependentChangeq ~ t "experiments3.contrast.responseRateq ~ t experiments5.locations0.Extendq ~ t  experiments1.locations0.SPI_Unitt tt population0sexMatchedControlsq ~ -t  tasks3.External_variables.lengtht 2t population1ageOfOnsett 0t #experiments0.locations4.Location_IDt 4t &experiments6.locations2.Coordinates[2]t 45.0t 'experiments0.locations11.Coordinates[2]t 41.0t &experiments0.locations9.Coordinates[2]t -16.0t experiments1.Namet %2-Back Degraded vs. Fixation, Normalst &experiments4.contrast.externalVariableq ~ t $experiments1.locations18.Location_IDt 18t &experiments0.locations3.Coordinates[0]t 48.0t ,experiments1.functional_modalities0.Commentst  t &experiments1.locations6.Coordinates[1]t 22.0t &tasks4.instractions0.Instruction_descrt  t Noteq ~ -t experiments1.experiment_class0q ~ t tasks1.Descriptiont  t $experiments3.population_groups_used1q ~6t $experiments3.population_groups_used0t Schizophrenic Patientst $experiments1.locations12.Location_IDt 12t Countryt Germanyt experiments2.conditions1q ~t experiments2.conditions0t 2-Backt experiments5.locations.lengtht 1t !experiments4.contrast.descriptiont  t &experiments1.Behavioral_domain0.effectt Cognition.Memory.Workingt &experiments6.locations2.Coordinates[1]t -44.0t page_tot 531t 'experiments0.locations11.Coordinates[1]t -41.0t &experiments0.locations9.Coordinates[1]t 21.0t #experiments0.locations5.Location_IDt 5t  experiments0.locations5.SPI_Unitt tt tasks4.stimuly0.Stimulus_typet Fixation Pointt new_journalq ~ -t experiments3.locations5.Extendq ~ t experiments0.imagingModalityt fMRIt $experiments1.locations1.Publ_SPI_Valt 10.45t $experiments2.locations3.Publ_SPI_Valt 4.65t &experiments4.locations0.Coordinates[2]t 6.0t "experiments3.contrast.stimulusTypeq ~ t &experiments1.locations6.Coordinates[0]t 46.0t population1.concurrentq ~ -t *experiments5.population_groups_used.lengtht 1t experiments6.locations2.Extendq ~ t $experiments1.locations19.Location_IDt 19t &experiments5.contrast.responseModalityq ~ t population0durationOfIllnessq ~ -t experiments1.locations12.Extendq ~ t $experiments1.locations13.Location_IDt 13t tasks1.response0.effectt Handt !tasks2.stimuly0.Stimulus_modalityq ~ /t &experiments0.locations7.Coordinates[2]t 3.0t experiments3.conditions1q ~t experiments3.conditions0q ~t &experiments6.locations2.Coordinates[0]t 30.0t 'experiments0.locations11.Coordinates[0]t 46.0t &experiments0.locations9.Coordinates[0]t 34.0t experiments2.Contexts0q ~ t #experiments0.locations6.Location_IDt 6t &experiments4.locations0.Coordinates[1]t -7.0t Prose_descriptiontMSchizophrenic patients and normal subjects underwent 2 sessions and 5 conditions.  Session 1:  Before Quetiapine.  Session 2:  After Quetiapine.  Condition 1:  0-Back:  subjects viewed letters on a black background and responded with a button press for the letter "X".  Condition 2:  0-Back Degraded:  subjects viewed letters on a blurred background and responded with a button press for the letter "X".  Condition 3:  2-Back:  subjects viewed letters on a black background and responded with a button press when the presented letter was the same as the one presented 2 letters back.  Condition 4:  2-Back Degraded:  subjects viewed letters on a blurry background and responded with a button press when the presented letter was the same as the one presented 2 letters back.  Condition 5:  Fixation.  Experiment 1:  2-Back vs. Fixation, Normals.  Experiment 2:  2-Back Degraded vs. Fixation, Normals.  Experiment 3:  2-Back vs. Fixation, Normals vs. Schizophrenics, Before Treatment.  Experiment 4:  2-Back Degraded vs. Fixation, Normals vs. Schizophrenics, Before Treatment.  Experiment 5:  2-Back Degraded vs. Fixation, Schizophrenics vs. Normals, Before Treatment.  Experiment 6:  2-Back vs. Fixation, Schizophrenics, After Treatment vs. Before Treatment.  Experiment 7:  2-Back Degraded vs. Fixation, Schizophrenics, After Treatment vs. Before Treatment.t #experiments0.locations0.Location_IDt 0t !experiments6.contrast.instructionq ~ t !population0.icdSpecficCode.lengthq ~Et "experiments1.contrast.responseTypeq ~ t %experiments0.locations19.Publ_SPI_Valt 7.89t submiter.Coder_Namet Sarah Thelent 	keywords4t %functional magnetic resonance imagingt experiments3.locations0.Extendq ~ t 	keywords3t 
quetiapinet ,experiments4.functional_modalities0.Commentst  t &experiments0.locations7.Coordinates[1]t -19.0t 	keywords2t neuroleptic treatmentt $experiments1.locations14.Location_IDt 14t 	keywords1t schizophreniat 	keywords0t working memoryt experiments3.Sessions0q ~ t sessions.lengtht 2t experiments4.conditions1q ~t experiments4.conditions0q ~t  experiments2.locations6.SPI_Unitt tt &experiments4.locations0.Coordinates[0]t -59.0t #experiments0.locations7.Location_IDt 7t !experiments1.locations16.SPI_Unitt tt "experiments6.contrast.responseTypeq ~ t 'experiments0.locations15.Coordinates[2]t 15.0t tasks0.External_descriptiont  t !experiments0.locations17.SPI_Unitt tt experiments0.locations2.Extendq ~ t &experiments0.locations7.Coordinates[0]t 6.0t !experiments1.locations11.SPI_Unitt tt authors9t Riedel Mt authors8t 	Schmitt Gt authors7t 
Zetzsche Tt authors6t Koutsouleris Nt experiments5.conditions1q ~t tasks3.stimuly0.stimulusContentq ~ )t authors5t Frodl Tt experiments5.conditions0q ~t authors4t 
Wiesmann Mt isNotFittingq ~ t authors3t Ufer St authors2t Zipse Mt !experiments0.locations12.SPI_Unitt tt authors1t Scheuerecker Jt experiments2.Namet A2-Back vs. Fixation, Normals vs. Schizophrenics, Before Treatmentt authors0t Meisenzahl E Mt 'experiments0.locations15.Coordinates[1]t 42.0t $experiments6.population_groups_used0q ~t paper_idt 0t experiments3.locations.lengtht 6t %experiments1.locations14.Publ_SPI_Valt 6.44t experiments4.locations2.Extendq ~ t population1treatmentStatusq ~ -t &experiments6.Behavioral_domain0.effectq ~ 't $experiments0.locations7.Publ_SPI_Valt 6.91t $experiments4.locations0.Publ_SPI_Valt 6.05t experiments0.Contexts.lengtht 1t 
Completionq ~ t $experiments4.locations1.Publ_SPI_Valt 4.10t submitert existst tasks0.response.lengtht 1t 'experiments0.locations13.Coordinates[2]t 49.0t !experiments1.locations22.SPI_Unitt tt experiments6.conditions1q ~t $experiments0.experiment_class.lengtht 1t experiments5.lowLevelControlq ~ t experiments6.conditions0q ~t 'experiments0.locations15.Coordinates[0]t -34.0t population0Native_Langt Unknownt experiments0.conditions1q ~t tasks0.External_variables1t Reaction Timet experiments0.conditions0q ~t tasks0.External_variables0t Accuracyt $experiments1.locations20.Location_IDt 20t #experiments2.locations0.Location_IDt 0t tasks0.stimuly0.stimulusContentq ~ )t 	page_fromt 522t experiments5.conditions.lengtht 2t  experiments4.locations2.SPI_Unitt tt "experiments2.contrast.stimulusRateq ~ t experiments2.locations7.Extendq ~ t 	authors14t 
Moller H Jt %experiments0.locations11.Publ_SPI_Valt 5.96t 	authors13t Bruckmann Ht 	authors12t Linn Jt 	authors11t 	Dehning St  experiments1.locations5.SPI_Unitt tt 	authors10t Spellmann It 'experiments0.locations13.Coordinates[1]t -60.0t %experiments0.locations12.Publ_SPI_Valt 5.67t sessions0.Descriptiont 8Subjects were scanned prior to receiving any medication.t ,experiments1.functional_modalities0.Modalityq ~t  tasks1.External_variables.lengtht 2t experiments6.commentst  t #experiments2.locations7.Location_IDt 7t population1Native_Langq ~~t &experiments4.locations2.Coordinates[2]t 12.0t $experiments1.locations21.Location_IDt 21t #experiments2.locations1.Location_IDt 1t 'experiments0.locations19.Coordinates[2]t 28.0t !experiments0.contrast.instructionq ~ t &experiments2.contrast.externalVariableq ~ t tasks0.stimuly0.Stimulus_descrt -subjects viewed letters on a black backgroundt experiments1.commentsq ~t 'experiments1.locations11.Coordinates[2]t 25.0t experiments0.locations17.Extendq ~ t experiments1.locations17.Extendq ~ t 'experiments0.locations13.Coordinates[0]t 32.0t submiter.Coder_Emailt ThelenS@uthscsa.edut "experiments0.contrast.responseRateq ~ t experiments1.locations20.Extendq ~ t population0medicationq ~ -t sessions1.DescriptiontBSubjects were scanned after 12 weeks of steady state treatment with quetiapine.  On Day 1 of treatment they received 50 mg, on Day 2 they received 100 mg, followed by daily increases of 100 mg/day to 600 mg/day on Day 7.  After Day 7 the dose of medication was adjusted according to the investigators' clinical judgement. t &experiments4.locations2.Coordinates[1]t -25.0t Yeart 2006t experiments2.locations2.Extendq ~ t  tasks4.instractions0.Instructiont Fixatet 'experiments0.locations19.Coordinates[1]t 32.0t %experiments5.Behavioral_domain.lengtht 2t $experiments1.locations22.Location_IDt 22t &experiments2.locations0.Coordinates[2]t 2.0t #experiments2.locations2.Location_IDt 2t 'experiments1.locations11.Coordinates[1]t -28.0t "experiments5.contrast.responseRateq ~ t experiments1.locations.lengtht 23t &experiments3.contrast.responseModalityq ~ t tasks.lengtht 5t experiments3.Namet J2-Back Degraded vs. Fixation, Normals vs. Schizophrenics, Before Treatmentt &experiments4.locations2.Coordinates[0]t -51.0t $experiments0.locations0.Publ_SPI_Valt 6.02t $experiments1.locations2.Publ_SPI_Valt 12.37t $experiments2.locations4.Publ_SPI_Valt 4.27t 'experiments0.locations17.Coordinates[2]t 18.0t $experiments2.locations5.Publ_SPI_Valt 4.13t experiments0.locations12.Extendq ~ t ,experiments4.functional_modalities0.Modalityq ~ t 'experiments0.locations19.Coordinates[0]t 2.0t &experiments2.locations0.Coordinates[1]t -12.0t !tasks3.stimuly0.Stimulus_modalityq ~ /t  experiments3.locations1.SPI_Unitt tt &experiments3.locations3.Coordinates[2]t 20.0t 'experiments1.locations11.Coordinates[0]t 6.0t experiments3.conditions.lengtht 2t #experiments2.locations3.Location_IDt 3t "experiments0.contrast.stimulusTypeq ~ t %experiments1.locations20.Publ_SPI_Valt 5.08t experiments1.imagingModalityq ~t experiments3.contrast.groupq ~ t *experiments4.population_groups_used.lengtht 2t experiments0.locations7.Extendq ~ t $experiments3.experiment_class.lengtht 1t experiments0.Sessions.lengtht 1t  experiments0.locations4.SPI_Unitt tt population0Mean_Aget 34t %experiments2.Behavioral_domain.lengtht 1t !experiments3.contrast.descriptiont  t experiments3.locations4.Extendq ~ t 'experiments0.locations17.Coordinates[1]t 36.0t &experiments2.locations0.Coordinates[0]t -10.0t "experiments5.contrast.stimulusTypeq ~ t &experiments3.locations3.Coordinates[1]t -38.0t experiments6.locations1.Extendq ~ t #experiments2.locations4.Location_IDt 4t 'experiments1.locations15.Coordinates[2]t 4.0t 'experiments0.locations17.Coordinates[0]t -2.0t tasks1.External_variables1q ~t tasks1.External_variables0t Accuracyt &experiments3.locations1.Coordinates[2]t 29.0t tasks3.stimuly0.Stimulus_descrt .subjects viewed letters on a blurry backgroundt &experiments3.locations3.Coordinates[0]t 44.0t /experiments3.contrast.experienceDependentChangeq ~ t experiments1.contrast.groupq ~ t &experiments4.contrast.stimulusModalityq ~ t experiments1.locations9.Extendq ~ t "experiments3.contrast.responseTypeq ~ t tasks2.response0.Responce_typet Button Presst experiments3.drugEffects.lengthq ~Et experiments4.drugEffects.lengthq ~Et experiments5.drugEffects.lengtht 1t experiments6.drugEffects.lengtht 1t !experiments5.contrast.instructionq ~ t &experiments2.locations4.Coordinates[2]t 9.0t #experiments2.locations5.Location_IDt 5t &experiments4.Behavioral_domain0.effectq ~ t Cityt Municht 'experiments1.locations15.Coordinates[1]t -13.0t  experiments2.locations5.SPI_Unitt tt $experiments0.locations15.Location_IDt 15t !experiments1.locations15.SPI_Unitt tt %population0externalAssessments.lengtht 1t &experiments3.locations1.Coordinates[1]t 17.0t experiments3.Contexts0q ~ t %experiments1.locations15.Publ_SPI_Valt 5.19t  experiments2.locations0.SPI_Unitt tt !experiments0.locations16.SPI_Unitt tt experiments1.conditions.lengtht 2t %experiments1.locations16.Publ_SPI_Valt 5.72t !experiments1.locations10.SPI_Unitt tt $experiments0.locations8.Publ_SPI_Valt 7.74t population0.diagnoses.lengtht 1t &experiments2.locations4.Coordinates[1]t 0.0t 'experiments1.locations13.Coordinates[2]t 28.0t $experiments0.locations9.Publ_SPI_Valt 7.20t 'experiments1.locations15.Coordinates[0]t 6.0t $experiments3.locations0.Publ_SPI_Valt 4.78t $experiments4.locations2.Publ_SPI_Valt 4.01t #experiments2.locations6.Location_IDt 6t population0Genderq ~yt !experiments0.locations11.SPI_Unitt tt experiments4.Sessions0q ~ t submiter.Coder_Phonet 210.567.8175t experiments4.Namet J2-Back Degraded vs. Fixation, Schizophrenics vs. Normals, Before Treatmentt $experiments0.locations16.Location_IDt 16t &experiments3.locations1.Coordinates[0]t 44.0t experiments5.singleSubjectq ~ t experiments1.locations4.Extendq ~ t $experiments0.locations10.Location_IDt 10t tasks3.response0.descriptiont  t experiments1.Contexts.lengtht 1t population0.Diagnosis_Desct 11 Males, 1 Female
9 patients were drug naive and 3 had been washed out over a period of 3 days, ending 2 days before the beginning of the trial.t experiments4.locations1.Extendq ~ t vaq ~ot &experiments2.locations2.Coordinates[2]t -6.0t $experiments6.experiment_class.lengtht 1t tasks1.response.lengtht 1t &tasks0.instractions0.Instruction_descrt 9subjects responded with a button press for the letter "X"t &experiments2.locations4.Coordinates[0]t 24.0t 'experiments1.locations13.Coordinates[1]t 27.0t population0Total_Subjectst 12t population1Age_Fromt 22t experiments6.lowLevelControlq ~ t &experiments0.contrast.externalVariableq ~ t !experiments1.locations21.SPI_Unitt tt %experiments0.locations13.Publ_SPI_Valt 5.63t experiments2.Contexts.lengtht 1t $experiments0.locations17.Location_IDt 17t 'experiments1.locations19.Coordinates[2]t 44.0t tasks2.response.lengtht 1t $experiments0.locations11.Location_IDt 11t &experiments2.locations2.Coordinates[1]t 23.0t experiments2.singleSubjectq ~ t  experiments4.locations1.SPI_Unitt tt &experiments3.locations5.Coordinates[2]t 23.0t 'experiments1.locations13.Coordinates[0]t 8.0t experiments5.contrast.sessionq ~ t  tasks2.instractions0.Instructiont Recallt experiments5.contrast.groupq ~ t &experiments0.locations0.Coordinates[2]t -9.0t  experiments1.locations4.SPI_Unitt tt experiments1.contrast.sessionq ~ t experiments2.locations6.Extendq ~ t population1Age_Tot 48t experiments5.commentsq ~ #t &experiments1.contrast.responseModalityq ~ t va.brainTemplatet Unknownt volumet 256t 'experiments1.locations19.Coordinates[1]t -68.0t Commentst  t $experiments0.locations18.Location_IDt 18t 'experiments1.locations21.Coordinates[2]t 7.0t &experiments2.locations2.Coordinates[0]t 28.0t $experiments2.population_groups_used1q ~6t $experiments2.population_groups_used0q ~t &experiments3.locations5.Coordinates[1]t -26.0t $experiments0.locations12.Location_IDt 12t experiments0.commentst  t population1handednessRatioq ~ -t &experiments0.locations0.Coordinates[1]t 21.0t &experiments1.locations3.Coordinates[2]t -11.0t ,experiments0.functional_modalities0.Commentsq ~t experiments1.locations16.Extendq ~ t &tasks3.instractions0.Instruction_descrt psubjects esponded with a button press when the presented letter was the same as the one presented 2 letters backt experiments0.locations16.Extendq ~ t 	http_linkq ~ -t 'experiments1.locations17.Coordinates[2]t -9.0t "experiments2.contrast.responseRateq ~ t  experiments0.locations9.SPI_Unitt tt 'experiments1.locations19.Coordinates[0]t -12.0t $experiments1.locations3.Publ_SPI_Valt 6.92t $experiments0.locations1.Publ_SPI_Valt 8.98t !tasks4.stimuly0.Stimulus_modalityt Visualt #experiments4.locations0.Location_IDt 0t tasks2.External_variables1q ~t tasks2.External_variables0t Accuracyt 'experiments1.locations21.Coordinates[1]t 16.0t $experiments1.locations4.Publ_SPI_Valt 11.10t $experiments2.locations6.Publ_SPI_Valt 3.98t &experiments3.locations5.Coordinates[0]t 12.0t $experiments0.locations19.Location_IDt 19t tasks4.task_nameq ~t experiments2.locations1.Extendq ~ t  experiments6.locations2.SPI_Unitt tt keywords.lengtht 5t $experiments0.locations13.Location_IDt 13t &experiments0.locations0.Coordinates[0]t -49.0t %experiments1.locations21.Publ_SPI_Valt 4.95t &experiments1.locations3.Coordinates[1]t 23.0t &experiments2.locations6.Coordinates[2]t 12.0t tasks1.stimuly0.Stimulus_typeq ~ t  experiments3.locations5.SPI_Unitt tt 'experiments1.locations17.Coordinates[1]t 46.0t tasks4.response0.effectt Nonet tasks4.External_descriptiont  t population0genderRatioq ~ -t *experiments3.population_groups_used.lengtht 2t experiments5.Namet I2-Back vs. Fixation, Schizophrenics, After Treatment vs. Before Treatmentt 'experiments1.locations21.Coordinates[0]t -53.0t #experiments4.locations1.Location_IDt 1t experiments2.imagingModalityq ~ t population1medicationq ~ -t  experiments3.locations0.SPI_Unitt tt experiments1.Sessions.lengtht 1t experiments0.locations11.Extendq ~ t experiments1.locations11.Extendq ~ t &experiments1.locations1.Coordinates[2]t 46.0t *experiments2.population_groups_used.lengtht 2t &experiments5.contrast.externalVariableq ~ t &experiments1.locations3.Coordinates[0]t -48.0t $experiments0.locations14.Location_IDt 14t "experiments2.contrast.stimulusTypeq ~ t  experiments0.locations3.SPI_Unitt tt &experiments2.locations6.Coordinates[1]t 49.0t &experiments2.contrast.stimulusModalityq ~ t )experiments6.functional_modalities.lengtht 1t 'experiments1.locations17.Coordinates[0]t 30.0t experiments0.locations6.Extendq ~ t population1genderRatioq ~ -t ,experiments3.functional_modalities0.Commentst  t &experiments2.Behavioral_domain0.effectq ~ t experiments3.imagingModalityq ~ t experiments3.contrast.sessionq ~ t experiments3.locations3.Extendq ~ t tasks0.task_namet 0-Backt #experiments4.locations2.Location_IDt 2t !experiments2.contrast.descriptiont  t &experiments1.locations1.Coordinates[1]t -42.0t experiments0.drugEffects.lengthq ~Et experiments1.drugEffects.lengthq ~Et experiments2.drugEffects.lengthq ~Et experiments6.locations0.Extendq ~ t &experiments2.locations6.Coordinates[0]t -30.0t tasks3.stimuly.lengtht 1t &experiments6.contrast.responseModalityq ~ t population0.IDCq ~ -t "experiments0.contrast.responseTypeq ~ t &experiments1.locations7.Coordinates[2]t 42.0t $experiments5.population_groups_used0q ~t experiments2.experiment_class0q ~ t paperVersiont 39.0t &experiments1.locations1.Coordinates[0]t -46.0t #experiments4.locations3.Location_IDt 3t experiments0.locations1.Extendq ~ t %experiments1.locations17.Publ_SPI_Valt 5.58t "experiments5.contrast.responseTypeq ~ t journalt 9European Archives of Psychiatry and Clinical Neurosciencet experiments1.locations8.Extendq ~ t  experiments2.locations4.SPI_Unitt tt &experiments0.locations2.Coordinates[2]t 48.0t $experiments3.locations1.Publ_SPI_Valt 4.63t $experiments4.locations3.Publ_SPI_Valt 3.83t !experiments1.locations14.SPI_Unitt tt tasks3.stimuly0.Stimulus_typeq ~ t &experiments1.locations7.Coordinates[1]t -58.0t population0.diagnoses0t Schizophreniat (population1.icdSpecficDescription.lengthq ~Et !experiments4.contrast.instructionq ~ t experiments6.experiment_class0q ~ t population1durationOfIllnessq ~ -t !experiments0.locations15.SPI_Unitt tt ,experiments6.functional_modalities0.Commentsq ~t tasks2.response0.effectt Handt tasks1.stimuly.lengtht 1t tasks2.stimuly0.stimulusContentq ~ )t tasks0.response0.descriptiont  t &experiments0.locations2.Coordinates[1]t -44.0t &experiments1.locations5.Coordinates[2]t 36.0t !experiments0.locations10.SPI_Unitt tt &experiments1.locations7.Coordinates[0]t 30.0t  tasks0.instractions0.Instructionq ~ {t )experiments5.functional_modalities.lengtht 1t %experiments0.locations14.Publ_SPI_Valt 5.54t  experiments1.locations9.SPI_Unitt tt experiments6.Namet R2-Back Degraded vs. Fixation, Schizophrenics, After Treatment vs. Before Treatmentt (population1.icdGeneralDescription.lengthq ~Et population1.diagnoses0t Normalst experiments5.drugEffects0t 3Pharmacology.Psychiatric Medications.Antipsychoticst tasks3.External_variables1q ~t tasks3.External_variables0t Accuracyt experiments1.locations3.Extendq ~ t &experiments6.locations1.Coordinates[2]t 1.0t experiments4.Contexts0q ~ t ,experiments0.functional_modalities0.Modalityq ~t experiments4.locations0.Extendq ~ t "experiments4.contrast.stimulusRateq ~ t &experiments0.locations2.Coordinates[0]t -42.0t experiments0.Sessions0q ~ t population1ageMatchedControlsq ~ -t !population1.icdGeneralCode.lengthq ~Et &experiments1.locations5.Coordinates[1]t 10.0t experiments3.Contexts.lengtht 1t !experiments1.locations20.SPI_Unitt tt tasks3.response.lengtht 1t /experiments4.contrast.experienceDependentChangeq ~ t &experiments6.locations1.Coordinates[1]t -58.0t experiments5.Sessions1q ~ t experiments5.Sessions0q ~ t experiments0.experiment_class0q ~ t  experiments4.locations0.SPI_Unitt tt experiments4.Contexts.lengtht 1t &experiments1.locations5.Coordinates[0]t -42.0t  experiments1.locations3.SPI_Unitt tt tasks4.response.lengtht 1t experiments4.commentsq ~t va.mriFieldStrengthq ~ It population0externalAssessments0t Nonet hasOtherDBComponentq ~ t experiments2.locations5.Extendq ~ t population0.Diagnosisq ~ot &experiments0.locations6.Coordinates[2]t 9.0t $experiments0.locations2.Publ_SPI_Valt 5.65t experiments4.experiment_class0q ~ t &experiments6.locations1.Coordinates[0]t 16.0t (population0.icdSpecficDescription.lengthq ~Et $experiments1.locations5.Publ_SPI_Valt 8.52t $experiments2.locations7.Publ_SPI_Valt 5.86t $experiments6.locations0.Publ_SPI_Valt 5.55t experiments0.Contexts0t Normal Mappingt sessions0.Nameq ~ t $experiments6.locations1.Publ_SPI_Valt 5.52t %experiments1.locations22.Publ_SPI_Valt 4.87t tasks0.instractions.lengtht 1t $experiments2.experiment_class.lengtht 1t ,experiments3.functional_modalities0.Modalityq ~ t  tasks4.External_variables.lengtht 1t &experiments3.contrast.externalVariableq ~ t tasks0.response0.effectt Handt experiments0.locations15.Extendq ~ t  experiments0.locations8.SPI_Unitt tt experiments1.locations15.Extendq ~ t &experiments0.locations6.Coordinates[1]t 2.0t &experiments0.contrast.stimulusModalityq ~ t &experiments1.locations9.Coordinates[2]t 19.0t %experiments4.Behavioral_domain.lengtht 1t )experiments4.functional_modalities.lengtht 1t #experiments1.locations0.Location_IDt 0t (population0.icdGeneralDescription.lengthq ~Et  experiments6.locations1.SPI_Unitt tt population0Age_Fromt 20t experiments2.locations0.Extendq ~ t titlet Effects of treatment with the atypical neuroleptic quetiapine on working memory function: A functional MRI follow-up investigationt /experiments0.contrast.experienceDependentChangeq ~ t  experiments3.locations4.SPI_Unitt tt &experiments0.locations4.Coordinates[2]t 15.0t &experiments0.locations6.Coordinates[0]t -10.0t *experiments1.population_groups_used.lengtht 1t &experiments1.locations9.Coordinates[1]t 32.0t experiments2.Sessions.lengtht 1t &experiments4.contrast.responseModalityq ~ t tasks3.External_descriptiont  t #experiments1.locations1.Location_IDt 1t tasks2.stimuly0.Stimulus_descrt -subjects viewed letters on a black backgroundt &experiments5.locations0.Coordinates[2]t 2.0t population1sexMatchedControlsq ~ -t %experiments1.Behavioral_domain.lengtht 1t experiments1.locations10.Extendq ~ t experiments0.locations10.Extendq ~ t  experiments0.locations2.SPI_Unitt tt tasks1.response0.Responce_typet Button Presst &experiments0.locations4.Coordinates[1]t 22.0t experiments4.imagingModalityq ~ t population0treatmentStatusq ~ -t experiments3.Sessions.lengtht 1t &experiments1.locations9.Coordinates[0]t -6.0t experiments0.locations5.Extendq ~ t #experiments6.locations0.Location_IDt 0t ,experiments6.functional_modalities0.Modalityq ~ t tasks4.External_variables0q ~t !experiments1.locations19.SPI_Unitt tt #experiments1.locations8.Location_IDt 8t &experiments5.locations0.Coordinates[1]t 29.0t experiments6.locations.lengtht 3t experiments3.locations2.Extendq ~ t 'experiments0.locations12.Coordinates[2]t 24.0t #experiments1.locations2.Location_IDt 2t experiments2.locations.lengtht 8t %experiments1.locations18.Publ_SPI_Valt 5.50t experiments4.singleSubjectq ~ t &experiments0.locations4.Coordinates[0]t 51.0t !experiments1.contrast.descriptiont  t $experiments2.locations0.Publ_SPI_Valt 5.94t $experiments3.locations2.Publ_SPI_Valt 4.47t &experiments5.Behavioral_domain1.effectq ~t va.mriResolutionq ~ It "experiments2.contrast.responseTypeq ~ t #experiments6.locations1.Location_IDt 1t &experiments5.locations0.Coordinates[0]t -28.0t experiments0.lowLevelControlq ~ t 'experiments0.locations12.Coordinates[1]t -40.0t #experiments1.locations9.Location_IDt 9t  experiments5.locations0.SPI_Unitt tt )experiments3.functional_modalities.lengtht 1t #experiments1.locations3.Location_IDt 3t $experiments5.experiment_class.lengtht 1t sessions1.Nameq ~ t experiments0.locations0.Extendt  t tasks1.task_namet 0-Back Degradedt &experiments4.locations1.Coordinates[2]t 16.0t  experiments2.locations3.SPI_Unitt tt experiments1.locations7.Extendq ~ t &experiments5.contrast.stimulusModalityq ~ t !experiments1.locations13.SPI_Unitt tt population1externalAssessments0q ~t experiments1.singleSubjectq ~ t %experiments0.locations15.Publ_SPI_Valt 5.09t 'experiments1.locations10.Coordinates[2]t 21.0t 'experiments0.locations10.Coordinates[2]t 26.0t &experiments0.locations8.Coordinates[2]t 29.0t experiments6.drugEffects0q ~)t 'experiments0.locations12.Coordinates[0]t -63.0t #experiments6.locations2.Location_IDt 2t !experiments0.locations14.SPI_Unitt tt %experiments0.locations16.Publ_SPI_Valt 4.58t !experiments3.contrast.instructionq ~ t %population1externalAssessments.lengtht 1t population0Age_Tot 48t Medline_numbert 17151834t &experiments4.locations1.Coordinates[1]t -21.0t #experiments1.locations4.Location_IDt 4t va.imagingModalityq ~t submiter.coderTypet Research Assistantt tasks1.instractions.lengtht 1t tasks2.response0.descriptiont  t "experiments1.contrast.stimulusRateq ~ t  experiments1.locations8.SPI_Unitt tt 'experiments1.locations10.Coordinates[1]t 20.0t abstractBodyt?RESULTS: At baseline, healthy controls revealed increased activity in the frontal lobe, especially in regions of the prefrontal cortex. Compared to HC, SZ showed hypoactivation in the right dorsolateral prefrontal cortex (DLPFC) and the ventrolateral prefrontal cortex (VLPFC) bilaterally for the 2-back condition. In the 2-back degraded condition there was a hypoactivation in both, the right DLPFC and the VLPFC. Additionally, patients showed bilaterally decreased activation in the basalganglia in the 2-back and in the right caudatus in the 2-back degraded condition compared to healthy controls. After treatment with quetiapine, patients activations patterns were increased. The pre-post comparison of the 2-back condition revealed a significant increase of activation in the left VLPFC at a significance level of 0.001 (uncorrected). The 2-back degraded condition led to a significant activation pattern in the lingual gyrus and the right precuneus. In both wm conditions, at baseline there were no differences in reaction time but only a worse performance in SZ. After treatment, behavioural measurement of responses, including reaction time and performance, showed slight improvements in SZ, although these did not reach statistical significance. CONCLUSIONS: The neuronal networks underlying working memory are clearly altered in schizophrenia. After 12 weeks of treatment with quetiapine monotherapy, patients showed significant clinical improvement and revealed increased BOLD activity in the VLPFC during a working memory task, although there was no improvement of cognitive performance.t population0.Nameq ~t 'experiments0.locations10.Coordinates[1]t 23.0t &experiments0.locations8.Coordinates[1]t 1.0t )population1externalAssessmentsDescriptionq ~ -t experiments1.locations2.Extendq ~ t tasks4.response0.Responce_typeq ~t &experiments4.locations1.Coordinates[0]t -61.0t $experiments1.population_groups_used0q ~6t 'experiments0.locations16.Coordinates[2]t 40.0t "experiments6.contrast.stimulusRateq ~ t #experiments1.locations5.Location_IDt 5t experiments4.locations.lengtht 4t %experiments1.locations10.Publ_SPI_Valt 4.98t &experiments3.locations2.Coordinates[2]t 12.0t 'experiments1.locations10.Coordinates[0]t -4.0t experiments0.locations.lengtht 20t va.templateOrigint ACt 'experiments0.locations10.Coordinates[0]t -46.0t &experiments0.locations8.Coordinates[0]t -40.0t $experiments0.locations3.Publ_SPI_Valt 8.34t  tasks2.External_variables.lengtht 2t &experiments1.contrast.externalVariableq ~ t va.braint 	Talairacht experiments5.Contexts.lengtht 2t Last_edited_datet 2015-09-02 15:24:30t $experiments0.locations4.Publ_SPI_Valt 4.09t $experiments1.locations6.Publ_SPI_Valt 9.52t &tasks2.instractions0.Instruction_descrt qsubjects responded with a button press when the presented letter was the same as the one presented 2 letters backt population1.diagnoses.lengtht 1t population0ageOfOnsett 0t experiments0.locations19.Extendq ~ t experiments1.locations19.Extendq ~ t 'experiments0.locations16.Coordinates[1]t 10.0t )experiments2.functional_modalities.lengtht 1t $experiments6.locations2.Publ_SPI_Valt 4.76t sparseq ~ t  experiments1.locations2.SPI_Unitt tt va.transformt Brett Transformt experiments5.Contexts1q ~ t &experiments3.locations2.Coordinates[1]t 18.0t experiments5.Contexts0q ~ t experiments3.commentsq ~8t population0handin_typet Rightt #experiments1.locations6.Location_IDt 6t "experiments4.contrast.responseRateq ~ t !experiments6.contrast.descriptiont  t experiments1.Sessions0q ~ t  tasks3.instractions0.Instructionq ~t experiments2.locations4.Extendq ~ t &experiments0.Behavioral_domain0.effectq ~t searchListVersiont 431t experiments6.conditions.lengtht 2t 'experiments1.locations14.Coordinates[2]t 8.0t 'experiments0.locations14.Coordinates[2]t 7.0t experiments0.activationsq ~ t 'experiments0.locations16.Coordinates[0]t -42.0t &experiments3.locations0.Coordinates[2]t 41.0t pubtypet (Original Research Article, Peer Reviewedt &experiments3.locations2.Coordinates[0]t 51.0t experiments0.contrast.groupq ~ t  experiments0.locations7.SPI_Unitt tt population1handin_typeq ~t #experiments1.locations7.Location_IDt 7t population1.Diagnosis_Desct 11 Males, 1 Femalet experiments0.locations14.Extendq ~ t experiments1.locations14.Extendq ~ t 'experiments1.locations14.Coordinates[1]t -5.0t population1.Diagnosisq ~t *experiments0.population_groups_used.lengtht 1t 'experiments0.locations14.Coordinates[1]t 47.0t  experiments6.locations0.SPI_Unitt tt 	Other_Labq ~ -t experiments6.contrast.sessionq ~ t experiments0.locations9.Extendq ~ t &experiments3.locations0.Coordinates[1]t -37.0t experiments1.activationsq ~ t "experiments4.contrast.stimulusTypeq ~ t ,experiments2.functional_modalities0.Commentsq ~ t &experiments4.locations3.Coordinates[2]t 4.0t experiments1.Contexts0q ~t  experiments3.locations3.SPI_Unitt tt population1.Namet Normals t /experiments5.contrast.experienceDependentChangeq ~ t 'experiments1.locations12.Coordinates[2]t -9.0t 'experiments1.locations14.Coordinates[0]t -12.0t $experiments4.population_groups_used1q ~6t $experiments4.population_groups_used0q ~t 'experiments0.locations14.Coordinates[0]t -36.0t experiments5.imagingModalityq ~ t &experiments3.locations0.Coordinates[0]t 40.0t experiments0.conditions.lengtht 2t  experiments0.locations1.SPI_Unitt tt va.vbmSoftwaret SPM99t multisessionq ~ t %experiments1.locations19.Publ_SPI_Valt 5.26t experiments4.Sessions.lengtht 1t &experiments4.locations3.Coordinates[1]t -11.0t tasks2.instractions.lengtht 1t tasks2.External_descriptiont  t Montht Dect experiments2.activationsq ~ t )experiments1.functional_modalities.lengtht 1t !population1.icdSpecficCode.lengthq ~Et 
Lab.lengtht 1t $experiments2.locations1.Publ_SPI_Valt 5.53t $experiments3.locations3.Publ_SPI_Valt 4.07t &experiments2.locations1.Coordinates[2]t 1.0x